فعالية مستخلص الكركم العلاجية للأذية الكبدية والكلوية المحدثة بالاندوميتاسين

Abstract

This study aimed to determine the histological effect of Ethanolic extract of turmeric rhizomes in reducing or preventing hepatotoxicity and nephrotoxicity induced by Indomethacin in male albino mice, and the possibility of inclusion it, as a result, as a preventive botanical factor against side effects of this drug. This study, included 30 white mice, (Balb/c strain), which were divided into three experimental groups (10 mice in each). as follows: The first group control), was treated with oral cavity of DMSO 10% until the end of the experiment, while the second group was treated with oral cavity of indomethacin in a single dose 166 mg⁄kg for 6 hours to induce toxicity, whereas the third group was treated with oral cavity of indomethacin in a single dose 166 mg⁄kg for 6 hours, then treated with oral cavity of 300 mg⁄kg Ethanolic extract of turmeric rhizomes for 30 days.

 Results showed a presence of important hepatic and renal preventive effect of turmeric rhizome extract by keeping tissue structure of each liver and kidneys safe without significant effects.