The relationship between C-reactive protein (CRP), Lactate dehydrogenase (LDH) levels and tumor grade in early-stage breast cancer patients
Keywords:
Early-stage breast cancer, Tumor grade, C-reactive protein, CRP, lactate dehydrogenase, LDH.Abstract
Background: Breast cancer is the most common malignancy among women worldwide. Cancer cells promote a shift toward anaerobic glycolysis, which elevates LDH levels in the blood. CRP is a systemic inflammatory marker associated with an increased tumor activity. Multiple evidence suggests that elevated levels of both these markers are linked to increased tumor grade.
Objective: To investigate the relationship between CRP and LDH levels in patients with early-stage breast cancer.
Study Design: This study included 65 newly diagnosed patients with early-stage breast cancer attending the Chemotherapy and Radiotherapy Center at Latakia University Hospital. Venous blood samples were collected from the patients in Heparin tubes. CRP and LDH levels were then measured.
Results: A statistically significant relationship was found between CRP and LDH levels and tumor grade. Additionally, a weak positive relationship was found between CRP and LDH levels, with a correlation coefficient of rho = 0.32 and a statistically significant p-value (P = 0.01).
